非人灵长类研究平台

•  Lu, Z., He, S., Jiang, J., Zhuang, L., Wang, Y., Yang, G., Jiang, X., Nie, Y., Fu, J., Zhang, X., Lu, Y., Bian, X., Chang, H., Xiong, Z., Huang, X*.,Liu, Z*., Sun, Q*. (2022) Base-edited cynomolgus monkeys mimic core symptoms of STXBP1 encephalopathy. Mol. Ther. In Press
•  Zhen Liu*, Kui Li,, Yijun Cai, Qiming Liu, Tikui Zhang, Yong Lu, Yanhong Nie, Yan Wang, Zhiguang Yan, Yinwei Qu, Yuzhuo Li, Zhanyang Wang, Zhiqi Xiong*, Qiang Sun* (2021) Accelerated passage of gene-modified monkeys by hormone-induced precocious puberty NSR 10 1093
•  Wang, Zhanyang Li, Yuzhuo Yang, Xianfa Wang, Yan Nie, Yanhong Xu, Yuting Zhang, Xiaotong Lu, Yong Zhang, Tikui Liu, Qiming Jing, Naihe Liu, Zhen* Sun, Qiang* (2020) Mitochondrial replacement in macaque monkey offspring by first polar body transfer Cell research 0 1-4
•  Xiaozhen He, Wenfeng Chen, Zhen Liu, Guirong Yu, Youbang Chen, Yi-Jun Cai, Ling Sun, Wanli Xu, Lili Zhong, Caixi Gao, Jishen Chen, Minjie Zhang, Shengxi Yang, Yizhou Yao, Zhiping Zhang, Fujun Ma, Chen-Chen Zhang, Hui-Ping Lu, Bin Yu, Tian Lin Cheng, Juhui Qiu, Qing Sheng, Hai-Meng Zhou, Zhi-Rong Lv, Junjun Yan, Yongjian Zhou, Zilong Qiu, Zongbin Cui, Xi Zhang, Anming Meng, Qiang Sun*, Yufeng Yang*. (2020) Efficient and risk-reduced genome editing using double nicks enhanced by bacterial recombination factors in multiple species Nucleic Acids Research 48 e57
•  Zongyang Lu, Zhen Liu, Wei Mao, Xinying Wang, Xiaoguo Zheng, Shanshan Chen, Beibei Cao, Shisheng Huang, Xuliang Zhang, Tao Zhou, Yu Zhang, Xingxu Huang*, Qiang Sun*, Jia-Da Li*. (2020) Locus-specific DNA methylation of Mecp2 promoter leads to autism-like phenotypes in mice. Cell Death & Disease 11 1-11
•  Jianan Li, Zhen Liu, Shisheng Huang, Xiao Wang, Guanglei Li, Yuting Xu, Wenxia Yu, Shanshan Chen, Yu Zhang, Hanhui Ma, Zunfu Ke, Jia Chen*, Qiang Sun*,Xingxu Huang*. (2019) Efficient base editing in G/C-rich regions to model androgen insensitivity syndrome. Cell Research 29 174-176
•  Zhen Liu,Yijun Cai,Zhaodi Liao,Yuting Xu,Yan Wang,Zhanyang Wang, Xiaoyu Jiang, Yuzhuo Li, Yong Lu, Yanhong Nie, Xiaotong Zhang,Chunyang Li, Xinyan Bian, Mu-ming Poo, Hung-Chun Chang*, Qiang Sun* (2019) Cloning of a gene-edited macaque monkey by somatic cell nuclear transfer National Science Review 6 101-108
•  Peiyuan Qiu, Jian Jiang, Zhen Liu, Yijun Cai, Tao Huang, Yan Wang, Qiming Liu, Yanhong Nie, Fang Liu, Jiumu Cheng, Qing Li, Yun-Chi Tang, Mu-ming Poo, Qiang Sun*, Hung-Chun Chang*. (2019) BMAL1 knockout macaque monkeys display reduced sleep and psychiatric disorders. National Science Review 6 87-100
•  Hui Long, Yanhong Nie, Li Wang, Yong Lu, Yan Wang, Yijun Cai, Zhen Liu, Miaomiao Jia, Qifeng Lyu*, Yanping Kuang* and Qiang Sun*. (2018) Serum anti-Mullerian hormone predicts ovarian response in (Macaca fascicularis) monkeys. Endocrine Connections 7 983–989
•  Tao Zhang, Xin Jiang, Min Xu, Haifang Wang, Xiao Sang, Meiling Qin, Puhua Bao, Ruiqi Wang, Chenchen Zhang, Huiping Lu, Yuzhuo Li, Jin Ren, Hung-Chun Chang, Jun Yan, Qiang Sun*, Jin Xu*. (2018) Sleep and circadian abnormalities precede cognitive deficits in R521C FUS knockin rats Neurobiology of Aging 72 159-170.
•  Zhen Liu, Zongyang Lu, Guang Yang, Shisheng Huang, Guanglei Li2, Songjie Feng, Yajing Liu, Jianan Li,Wenxia Yu, Yu Zhang, Jia Chen ,Qiang Sun& Xingxu Huang. (2018) Efficient generation of mouse models of human diseases via ABE- and BE-mediated base editing Nature communication 9 2338
•  Zhen Liu, Yijun Cai, Yan Wang, Yanhong Nie, Chenchen Zhang, Yuting Xu, Xiaotong Zhang, Yong Lu,Zhanyang Wang, Muming Poo, andQiang Sun* (2018) Cloning of Macaque Monkeys by Somatic Cell Nuclear Transfer. Cell 172 881–887
•  Xuan Yao, Zhen Liu, Xing Wang, Yan Wang, Yan-Hong Nie, Liang Lai, Ruilin Sun, Linyu Shi,Qiang Sun*& Hui Yang* (2018) Generation of knock-in cynomolgus monkey via CRISPR/Cas9 editing Cell research
•  Tian, Y., Yang, C., Shang, S., Cai, Y., Deng, X., Zhang, J., Shao, F., Zhu, D., Liu, Y., Chen, G., Liang, J.*,Sun, Q.*,Qiu, Z.*, and Zhang, C.* (2017) Loss of FMRP impaired hippocampal long-term plasticity and spatial learning in rats. Front. Mol. Neurosci 10 269
•  Yao X,Wang X,Hu X,Liu Z,Liu J,Zhou H,Shen X,Wei Y,Huang Z,Ying W,Wang Y,Nie YH,Zhang CC,Li S,Cheng L,Wang Q,Wu Y,Huang P,Sun Q*, (2017) Homology-mediated end joining-based targeted integration usingCRISPR/Cas9. Cell Research 27(6) 801-814.
•  Zhen Liu, Yijun Cai,Qiang Sun. (2017) Genome editing of monkey. Methods in Molecular Biology
•  Erwei Zuo, Yijun Cai, Kui Li, Yu Wei, Bangan Wang, Yidi Sun, Zhen Liu, Jiwei Liu, Xinde Hu, Wei Wei, Xiaona Huo, Linyu Shi, Cheng Tang, Dan Liang, Yan Wang, Yanhong Nie, Chenchen Zhang, Xuan Yao, Xing Wang, Changyang Zhou, Wenqin Ying, Qifang Wang, Renchao Chen, Qi Shen, Guoliang Xu, Jinsong Li, Qiang Sun*, Zhiqi Xiong*, Hui Yang*. (2017) One-step generation of complete gene knockout mice and monkeys by CRISPR/Cas9-mediated gene editing with multiple sgRNAs Cell Research 27 933–945.
•  Zhen Liu, Xiao Li, Jun-Tao Zhang, Yi-Jun Cai, Tian-Lin Cheng, YanWang, Chen-Chen Zhang, Yan-Hong Nie, Wen-Jie Bian, Ling Zhang, Jian-Qiu Xiao, Bin Lu1, Yue-Fang Zhang, Xiao-Di Zhang, Xiao Sang, Jia-Jia Wu, Xiu Xu, Zhi-Qi Xiong, Feng Zhang, Xiang Yu, Neng Gong, Wen-Hao Zhou,Qiang Sun,*,Zilong Qiu,* (2016) Autism-like behaviors and germline transmission of transgenic monkeys expressing human MeCP2 Nature 530 98-102.
•  Zhen Liu,Yan-Hong Nie, Chen-Chen Zhang, Yi-Jun Cai, Yan Wang, Hui-Ping Lu, Yu-Zhuo Li,Cheng Cheng,Zi-Long Qiu,Qiang Sun*. (2016) Generation of macaques with sperm derived from juvenilemonkeytesticular xenografts. Cell Research 26 139-142.
•  Zhen Liu#, Xue Zhou#, Ying Zhu#, Zhi-Fang Chen, BinYu, Yan Wang, Chen-Chen Zhang, Yan-Hong Nie, Xiao Sang, Yi-Jun Cai, Yue-Fang Zhang, Tian-Lin Cheng, Chen Zhang, Wen-Hao Zhou,Qiang Sun,* Zilong Qiu,*. (2014) Generation of a monkey with MECP2 mutations by TALEN-based gene targeting. Neurosci Bull 30(3) 381–386.
•  Hui Yang, Zhen Liu, Yu Ma, Cuiqing Zhong, Qi Yin, Chikai Zhou, Yijun Cai, Hanzhi Zhao, Hui Wang, Fan Tang, Yan Wang, Chenchen Zhang, Dongmei Lai, Mu-ming Poo, Dangsheng Li, Ying Jin, *Qiang Sun, *and Jinsong Li,*. (2013) Generation of haploid embryonic stem cells from Macaca fascicularis monkey parthenotes. Cell Research 23 1187–1200.
•  Qiang Sun*,Juan Dong, Wenting Yang, Yujuan Jin, Mingying Yang, Yan Wang, Philip L. Wang, and Yinghe Hu*, and Joe Z. Tsien*. (2008) Efficient reproduction of cynomolgus monkey using pronuclear embryo transfer technique. PNAS. 2008 105(35) 12956-12960.
•  Sun Q,Wei X, Feng J, Zhang R, Shen Q, Dong J, Jin Y, Dong S, Li H, Hu Y. (2008) Involvement of insulin-like growth factor-insulin receptor signal pathway in the transgenic mouse model of medulloblastoma. Cancer Sci 99(2) 234-240.