代表性论文
| • Yu, X.*, Nollet M, Franks NP*, Wisden W*. (2025) Sleep and the recovery from stress. Neuron : In Press. |
| • Tossell， K.#, Yu, X.#, Giannos, P., Anuncibay Soto, B., Nollet, M., Yustos, R., Miracca, G., Vicente, M., Miao, A., Hsieh, B., Ma, Y., Vyssotski, AL., Constandinou, T., Franks NP.*, Wisden W.* (2023) Somatostatin neurons in prefrontal cortex initiate sleep-preparatory behavior and sleep via the preoptic and lateral hypothalamus. Nat. Neurosci. 26(10): 1805-1819. |
| • Yu, X. #*, Zhao, G. #, Wang, D., Wang, S., Li, R., Li, A., Wang, H., Nollet, M., Chun, Y. Y., Zhao, T., Yustos, R., Li, H., Zhao, J., Li, J., Cai, M., Vyssotski, A. L., Li, Y., Dong, H.*, Franks, N. P. *, and Wisden, W. * (2022) A specific circuit in the midbrain detects stress and induces restorative sleep. Science 377: 63-72 |
| • Yu, X. #*, Ba, W. #, Zhao, G. #, Ma, Y., Harding, E. C., Yin, L., Wang, D., Li, H., Zhang, P., Shi, Y., Yustos, R., Vyssotski, A. L., Dong, H.*, Franks, N. P. *, and Wisden, W. * (2021) Dysfunction of ventral tegmental area GABA neurons causes mania-like behavior. Mol. Psychiatry 26: 5213-5228 |
| • Yu, X. #, Li, W. #, Ma, Y., Tossell, K., Harris, J. J., Harding, E. C., Ba, W., Miracca, G., Wang, D., Li, L., Guo, J., Chen, M., Li, Y., Yustos, R., Vyssotski, A. L., Burdakov, D., Yang, Q., Dong, H. *, Franks, N. P. *, and Wisden, W. * (2019) GABA and glutamate neurons in the VTA regulate sleep and wakefulness. Nat. Neurosci. 22: 106-119 |
| • Yu, X. #, Ye, Z. #, Houston, Catriona M., Zecharia, Anna Y., Ma, Y., Zhang, Z., Uygun, David S., Parker, S., Vyssotski, Alexei L., Yustos, R., Franks, Nicholas P. *, Brickley, Stephen G. *, and Wisden, W. * (2015) Wakefulness Is Governed by GABA and Histamine Cotransmission. Neuron 87: 164-178 |
所有论文
| • Qu C, Yu X*. (2026) From illness to rest: neural circuits linking sickness and sleep Trends Neurosci. 26: S0166-2236(26)00012-3. |
| • Ji C, Zhang Y, Lin Z, Zhao Z, Jiao Z, Zheng Z, Shi X, Wang X, Li Z, Yu S, Qu Y, Wei Y, Rui T, Zheng B, Xie T, Shi H, Wang Q, Yu X, Xu X, Chen J, Fan J, Cai W*, Li Y*. (2025) Activation of hypothalamic-pontine-spinal pathway promotes locomotor initiation and functional recovery after spinal cord injury in mice Nat Commun. 17(1): 446 |
| • Yu, X.*, Nollet M, Franks NP*, Wisden W*. (2025) Sleep and the recovery from stress. Neuron : In Press. |
| • Ba, W., Nollet, M., Yin, C., Yu, X., Wong, S., Miao, A., Beckwith, EJ., Harding, EC., Ma, Y., Yustos, R., Vyssotski, AL., Wisden, W*., Franks, NP.* (2024) A REM-active basal ganglia circuit that regulates anxiety. Curr Biol. 34(15): 3301-3314. |
| • Tossell， K.#, Yu, X.#, Giannos, P., Anuncibay Soto, B., Nollet, M., Yustos, R., Miracca, G., Vicente, M., Miao, A., Hsieh, B., Ma, Y., Vyssotski, AL., Constandinou, T., Franks NP.*, Wisden W.* (2023) Somatostatin neurons in prefrontal cortex initiate sleep-preparatory behavior and sleep via the preoptic and lateral hypothalamus. Nat. Neurosci. 26(10): 1805-1819. |
| • Lucaci, D., Yu, X., Chadderton, P., Wisden, W., and Brickley, S. G. * (2023) Histamine release in the prefrontal cortex excites fast-spiking interneurons while GABA released from the same axons inhibits pyramidal cells. J. Neurosci.. 11: 187-198 |
| • Yu, X. #*, Zhao, G. #, Wang, D., Wang, S., Li, R., Li, A., Wang, H., Nollet, M., Chun, Y. Y., Zhao, T., Yustos, R., Li, H., Zhao, J., Li, J., Cai, M., Vyssotski, A. L., Li, Y., Dong, H.*, Franks, N. P. *, and Wisden, W. * (2022) A specific circuit in the midbrain detects stress and induces restorative sleep. Science 377: 63-72 |
| • Harding, E. C. *, Zhang, Z., Dong, H., and Yu, X.* (2022) Editorial: Behaviors and Neural Circuits in Sleep and Sedation. Front. Neurosci. 16: 930591 |
| • Yu, X. #*, Ba, W. #, Zhao, G. #, Ma, Y., Harding, E. C., Yin, L., Wang, D., Li, H., Zhang, P., Shi, Y., Yustos, R., Vyssotski, A. L., Dong, H.*, Franks, N. P. *, and Wisden, W. * (2021) Dysfunction of ventral tegmental area GABA neurons causes mania-like behavior. Mol. Psychiatry 26: 5213-5228 |
| • Yu, X., Franks, N. P., and Wisden, W. * (2021) Brain Clocks, Sleep, and Mood. Adv. Exp. Med. Biol. 1344: 71-86 |
| • Harding, E. C. *, Ba, W., Zahir, R., Yu, X., Yustos, R., Hsieh, B., Lignos, L., Vyssotski, A. L., Merkle, F. T., Constandinou, T. G., Franks, N. P. *, and Wisden, W. * (2021) Nitric Oxide Synthase Neurons in the Preoptic Hypothalamus Are NREM and REM Sleep-Active and Lower Body Temperature. Front. Neurosci. 15: 709825 |
| • Yu, X. #, Li, W. #, Ma, Y., Tossell, K., Harris, J. J., Harding, E. C., Ba, W., Miracca, G., Wang, D., Li, L., Guo, J., Chen, M., Li, Y., Yustos, R., Vyssotski, A. L., Burdakov, D., Yang, Q., Dong, H. *, Franks, N. P. *, and Wisden, W. * (2019) GABA and glutamate neurons in the VTA regulate sleep and wakefulness. Nat. Neurosci. 22: 106-119 |
| • Yu, X., Ma, Y., Harding, E. C., Yustos, R., Vyssotski, A. L., Franks, N. P. *, and Wisden, W. * (2019) Genetic lesioning of histamine neurons increases sleep–wake fragmentation and reveals their contribution to modafinil-induced wakefulness. Sleep 42: zsz031 |
| • Ma, Y., Miracca, G., Yu, X., Harding, E. C., Miao, A., Yustos, R., Vyssotski, A. L., Franks, N. P. *, and Wisden, W. * (2019) Galanin Neurons Unite Sleep Homeostasis and α2-Adrenergic Sedation. Curr. Biol. 29: 315-3322 |
| • Yu, X., Franks, N. P., and Wisden, W. * (2018) Sleep and Sedative States Induced by Targeting the Histamine and Noradrenergic Systems. Front. Neural Circuits 12: 4 |
| • Gelegen, C. #, Miracca, G. #, Ran, M. Z., Harding, E. C., Ye, Z., Yu, X., Tossell, K., Houston, C. M., Yustos, R., Hawkins, E. D., Vyssotski, A. L., Dong, H *. L., Wisden, W. *, and Franks, N. P. * (2018) Excitatory Pathways from the Lateral Habenula Enable Propofol-Induced Sedation. Curr. Biol. 28: 580-587 |
| • Harding, E. C., Yu, X., Miao, A., Andrews, N., Ma, Y., Ye, Z., Lignos, L., Miracca, G., Ba, W., Yustos, R., Vyssotski, A. L., Wisden, W. *, and Franks, N. P. * (2018) A Neuronal Hub Binding Sleep Initiation and Body Cooling in Response to a Warm External Stimulus. Curr. Biol. 28: 2263-2273 |
| • Ye, Z., Yu, X., Houston, C. M., Aboukhalil, Z., Franks, N. P., Wisden, W., and Brickley, S. G. * (2017) Fast and Slow Inhibition in the Visual Thalamus Is Influenced by Allocating GABA(A) Receptors with Different γ Subunits. Front. Cell Neurosci. 11: 95 |
| • Jager, P. #, Ye, Z. #, Yu, X., Zagoraiou, L., Prekop, H.-T., Partanen, J., Jessell, T. M., Wisden, W., Brickley, S. G. *, and Delogu, A. * (2016) Tectal-derived interneurons contribute to phasic and tonic inhibition in the visual thalamus. Nat. Commun. 7: 13579 |
| • Uygun, D. S., Ye, Z., Zecharia, A. Y., Harding, E. C., Yu, X., Yustos, R., Vyssotski, A. L., Brickley, S. G., Franks, N. P. *, and Wisden, W. * (2016) Bottom-Up versus Top-Down Induction of Sleep by Zolpidem Acting on Histaminergic and Neocortex Neurons. J. Neurosci. 36: 11171-11184 |
| • Zhang, Z. #, Ferretti, V. #, Güntan, ？., Moro, A., Steinberg, E. A., Ye, Z., Zecharia, A. Y., Yu, X., Vyssotski, A. L., Brickley, S. G., Yustos, R., Pillidge, Z. E., Harding, E. C., Wisden, W. *, and Franks, N. P. * (2015) Neuronal ensembles sufficient for recovery sleep and the sedative actions of α2 adrenergic agonists. Nat. Neurosci. 18: 553-561 |
| • Shen, N. #, Jiang, S. #, Lu, J.-M., Yu, X., Lai, S.-S., Zhang, J.-Z., Zhang, J.-L., Tao, W.-W., Wang, X.-X., Xu, N., Xue, B. *, and Li, C.-J. * (2015) The Constitutive Activation of Egr-1/C/EBPa Mediates the Development of Type 2 Diabetes Mellitus by Enhancing Hepatic Gluconeogenesis. Am. J. Pathol. 185: 513-523 |
| • Yu, X. #, Ye, Z. #, Houston, Catriona M., Zecharia, Anna Y., Ma, Y., Zhang, Z., Uygun, David S., Parker, S., Vyssotski, Alexei L., Yustos, R., Franks, Nicholas P. *, Brickley, Stephen G. *, and Wisden, W. * (2015) Wakefulness Is Governed by GABA and Histamine Cotransmission. Neuron 87: 164-178 |
| • Yu, X., Zecharia, A., Zhang, Z., Yang, Q., Yustos, R., Jager, P., Vyssotski, Alexei L., Maywood, Elizabeth S., Chesham, Johanna E., Ma, Y., Brickley, Stephen G., Hastings, Michael H., Franks, Nicholas P. *, and Wisden, W. * (2014) Circadian Factor BMAL1 in Histaminergic Neurons Regulates Sleep Architecture. Curr. Biol. 24: 2838-2844 |
| • Zecharia, A. Y., Yu, X., G？tz, T., Ye, Z., Carr, D. R., Wulff, P., Bettler, B., Vyssotski, A. L., Brickley, S. G., Franks, N. P. *, and Wisden, W. * (2012) GABAergic inhibition of histaminergic neurons regulates active waking but not the sleep-wake switch or propofol-induced loss of consciousness. J. Neurosci. 32: 13062-13075 |
| • Yu, X. #, Shen, N. #, Zhang, M. L. #, Pan, F. Y., Wang, C., Jia, W. P., Liu, C., Gao, Q., Gao, X., Xue, B. *, and Li, C. J. * (2011) Egr-1 decreases adipocyte insulin sensitivity by tilting PI3K/Akt and MAPK signal balance in mice. EMBO J. 30: 3754-3765 |
| • Shen, N. #, Yu, X.#, Pan, F.-Y., Gao, X., Xue, B., and Li, C.-J. * (2011) An Early Response Transcription Factor, Egr-1, Enhances Insulin Resistance in Type 2 Diabetes with Chronic Hyperinsulinism. J. Biol. Chem. 286: 14508-14515 |
| • Yu, X.#, Chen, J. #, Yu, X.., Tao, W., Jiang, F., Yin, Z., and Liu, C. * (2010) Protective effects of chlorogenic acid on acute hepatotoxicity induced by lipopolysaccharide in mice. Inflamm. Res. 59: 871-877 |
| • Yu, X., Tao, W., Jiang, F., Li, C., Lin, J., and Liu, C. (2010) Celastrol attenuates hypertension-induced inflammation and oxidative stress in vascular smooth muscle cells via induction of heme oxygenase-1. Am. J. Hypertens. 23: 895-903 |
