论文
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| • Shaoshuai Mao# , Wenbo Peng#, Zhengyan Feng#, Yang Chen#, Jing Sun#, Haiting Chen#, Pengcheng Wang , Pinzheng Huang , Junzheng Zhao , Leilei Wu , Yifan Wang , Junjian Liu , Hao Luo , Ying Zang , Changqing Yang , Xue Qiao , Zhiwei Lu , Hongjun Wu , Mingjie Chen , Di Sun , Jun Xie*, Yidi Sun*, Changyang Zhou (2025) Design of optimized epigenetic regulators for durable gene silencing with application to PCSK9 in nonhuman primates. Nat Biotechnol. Nature Biotechnology. : doi: 10.1038/s41587-025-02838-y. |
| • Liu Y#, Lou S#, Li J#, Liu Y, Huang S, Wei Y, Liu J, Lv R, Tang J, Shen Z, Sun Y, Huang X*, Xiong Z*, Yang H*, Zhou, C.* (2024) Epigenetic editing alleviates Angelman syndrome phenotype in mice by unsilencing paternal Ube3a. Cell Discov. 10（1）: 97 |
| • Wu L#, Jiang S#, Shi M#, Yuan T, Li Y, Huang P, Li Y, Zuo E*, Zhou, C.*, Sun Y*. (2024) Adenine base editors induce off-target structure variations in mouse embryos and primary human T cells Genome Biol. 25（1）: 291. |
| • Wei, Y., Zhou, Y., Liu, Y., Ying, W., Lv, R., Zhao, Q., Zhou, H., Zuo, E.*, Sun, Y.*, Yang, H.*, Zhou, C.* (2021) Indiscriminate ssDNA cleavage activity of CRISPR-Cas12a induces no detectable off-target effects in mouse embryos. Protein Cell 10: 1007 |
| • Liu, Y. #, Zhou, C.#, Huang, S.#, Dang, L.#, Wei, Y.#, He, J. Zhou, Y. Mao, S. Tao, W. Zhang, Y. Yang, H.*, Huang, X.*, Chi, T.* (2020) A Cas-Embedding Strategy for Minimizing Off-Target Effects of DNA Base Editors. Nat. Commun. 11(1): 6073 |
| • Zuo, E.*#, Sun, Y. #, Yuan, T. #, He, B. #, Zhou, C. #, Ying, W., Liu, J., Wei, W., Zeng, R., Li, Y.* &Yang H.* (2020) A rationally engineered cytosine base editor retains high on-target activity while reducing both DNA and RNA off-target effects. Nat. Methods 17: 600-604 |
| • Zhou, H.* #, Su, J. #, Hu, X. #, Zhou, C. #, Li, H. #, Chen, Z. #, Xiao, Q., Wang, B., Wu, W., Sun, Y., Zhou, Y., Tang, C., Liu, F., Wang, L., Feng, C., Liu, M., Li, S., Zhang, Y., Xu, H., Yao, H., Shi, L., &Yang H.* (2020) Glia-to-neuron conversion by CRISPR-CasRx alleviates symptoms of neurological disease in mice. Cell 181: 590-603 |
| • Zhou, C. #, Hu, X. #, Tang, C. #, Liu, W. #, Wang, S. #, Zhou, Y., Zhao, Q., Bo, Q., Shi, L., Sun, X.*, Zhou, H.*, &Yang H.* (2020) CasRx-mediated RNA targeting prevents choroidal neovascularization in a mouse model of age-related macular degeneration. Natl. Sci. Rev. 7: 835-837 |
| • Zhou, C. #, Sun, Y. #, Yan, R. #, Liu, Y. #, Zuo, E. #, Gu, C., Han, L., Wei, Y., Hu, X., Zeng, R., Li, Y.*, Zhou, H.*, Guo, F.*, &Yang H.* (2019) Off-target RNA mutation induced by DNA base editing and its elimination by mutagenesis. Nature 517: 275-278 |
| • Li, J. #, Lin, X. #, Tang, C. #, Lu, Y. #, Hu, X. #, Zuo, E., Li, H., Ying, W., Sun, Y., Lai, L., Chen, H., Guo, X., Zhang, Q., Wu, S., Zhou, C., Shen, X., Wang, Q., Lin, M., Ma, L., Wang, N., Krainer A.R., Shi, L.*, Yang, H.*, & Chen W.* (2019) Disruption of splicing-regulatory elements using CRISPR/Cas9 to rescue spinal muscular atrophy in human iPSCs and mice. Natl. Sci. Rev 7: 92-101 |
| • Liu, Y. #, Li, J. #, Zhou, C. #, Meng, B. #, Wei, Y., Yang, G., Lu, Z., Shen, Q., Zhang, Y., Yang, H.*, & Qiao, Y.* (2019) Allele-specific genome editing of imprinting genes by preferentially targeting non-methylated loci using Staphylococcus aureus Cas9 (SaCas9) Science Bull 64: 1592-1600 |
| • Zhang, M. #, Zhou, C. #, Wei, Y. #, Xu, C. #, Pan, H., Ying, W., Sun, Y., Sun, Y., Xiao, Q., Yao, N., Zhong, W., Li, Y., Wu, K., Yuan, G., Mitalipov, S.*, Chen, Z.*, &Yang, H.* (2019) Human cleaving embryos enable robust homozygotic nucleotide substitutions by base editors. Genome Biol 20: 101 |
| • Yang, G. #, Zhou, C. #, Wang, R. #, Huang, S., Wei, Y., Yang, X., Liu, Y., Li, J., Lu, Z., Ying, W., Li, X., Jing, N., Huang, X.*,Yang, H.*, & Qiao, Y.* (2019) Base-editing-mediated R17H substitution in histone H3 reveals methylation-dependent regulation of Yap signaling and early mouse embryo development. Cell Rep 26: 302-312 |
| • Zhang, H. #, Pan, H. #, Zhou, C. #, Wei, Y., Ying, W., Li, S., Wang, G., Li, C., Ren, Y., Li, G., Ding, X., Sun, Y., Li, G., Song, L., Li, Y.,Yang, H.*, & Liu, Z.* (2018) Simultaneous zygotic inactivation of multiple genes in mouse through CRISPR/Cas9-mediated base editing. Development 145: dev168906 |
| • Zhou, H. #, Liu, J. #, Zhou, C. #, Gao, N. #, Rao, Z. #, Li, H., Hu, X., Li, C., Yao, X., Shen, X., Sun, Y., Wei, Y., Liu, F., Ying, W., Zhang, J., Tang, C., Zhang, X., Xu, H., Shi, L., Cheng, L., Huang, P.*, &Yang, H.* (2018) In vivo simultaneous transcriptional activation of multiple genes in the brain using CRISPR–dCas9-activator transgenic mice. Nat. Neurosci 21: 440-446 |
| • Zhou, C. #, Zhang, M. #, Wei, Y. #, Sun, Y. #, Sun, Y., Pan, H., Yao, N., Zhong, W., Li, Y., Li, W.*, Yang, H.*, & Chen, Z.* (2017) Highly efficient base editing in human tripronuclear zygotes. Protein Cell 8: 772-775 |
| • Zuo, E. #, Cai, Y. #, Li, K. #, Wei, Y. #, Wang, B. #, Sun, Y., Liu, Z., Liu, J., Hu, X., Wei, W., Huo, X., Shi, L., Tang, C., Liang, D., Wang, Y., Nie, Y., Zhang, C., Yao, X., Wang, X., Zhou, C., Ying, W., Wang, Q., Chen, R., Shen, Q., Xu, G., Li, J., Sun, Q.*, Xiong, Z.*, &Yang, H.* (2017) One-step generation of complete gene knockout mice and monkeys by CRISPR/Cas9-mediated gene editing with multiple sgRNAs. Cell Res 27: 933-945 |
