非人灵长类研究平台

1. Jie Li*, Jie Li, Jing Cao, ShenShen Shang, Liansheng Zhang, Fei Gao, Jiqiang Fu, Hongyu Chen, Guizhong Cui, Haoyuan Wu, Xiaolong Wang*, Alfonso Martinez-Arias*, Qiang Sun*, Zhen Liu*. Modeling late gastrulation in stem cell-derived monkey embryo models. Nature. 2026, 649, 161–172. (Views and News reports by Nature; Cutting Edge comment by Vita)

2. Ling Li, Yiming Huang, Dengyu Lu, Jiqiang Fu, Luyan Wu, Zheyuan Chen, Haiou Liao, Jiaqi Zhang, Li Li, Tianyue Gu, Fang He, Hean Liu, Xiangqing Leng, Jing Tang, Jiaqi Yan, Cirong Liu, Chao Li, Huapin Huang, Lina Wang, Longqi Liu, Chengyu Li, Mu-ming Poo, Hao Li*, Yidi Sun*, Zhen Liu*. Identification and application of cell-type-specific enhancers for the macaque brain. Cell. 2025, 188, 1–19.

3. Wencheng Zhu*, Juan Meng, Yan Li, Lei Gu, Wenjun Liu, Ziyi Li, Yi Shen, Xiaoyu Shen, Zihong Wang, Yonggen Wu, Guiquan Wang, Junfeng Zhang, Huiping Zhang, Haiyan Yang, Xi Dong, Hui Wang, Xuefeng Huang, Yidi Sun*, Chen Li*, Liangshan Mu*, and Zhen Liu*. Comparative proteomic landscapes elucidate human preimplantation development and failure. Cell. 2025, 188(3): 814-831.e21. (Featured article)

4. Jing Cao, Wenjuan Li, Jie Li, Md. Abdul Mazid, Chunyang Li, Yu Jiang, Wenqi Jia, Zhaodi Liao, Shiyu Sun, Jiqiang Fu, Yan Wang, Yong Lu, Yuting Xu, Yanhong Nie, Xinyan Bian, Changshan Gao, Xiaotong Zhang, Liansheng Zhang, Yunpan Li, Lixin Fu, Hao Liu, Junjian Lai, Yang Wang, Yue Yuan, Yiwei Lai, Longqi Liu, Xiaolong Wang, Qiang Sun*, Miguel A. Esteban*, Zhen Liu*. Live birth of chimeric macaque monkey with high contribution from embryonic stem cells. Cell. 2023, 186, 4996–5014. (Cover story; News reports by Nature).

5. Jie Li, Qingyuan Zhu, Jing Cao, Ying Liu, Yong Lu, Yining Sun, Qian Li, Yiming Huang, Shenshen Shang, Xinyan Bian, Chunyang Li, Liansheng Zhang, Yan Wang, Yanhong Nie, Jiqiang Fu, Wenjuan Li, Md. Abdul Mazid, Yu Jiang, Wenqi Jia, Xiaolong Wang, Yidi Sun, Miguel A. Esteban, Qiang Sun*, Fan Zhou*, Zhen Liu*. Cynomolgus monkey embryo model captures gastrulation and early pregnancy. Cell Stem Cell. 2023, 30: 362–377. (Previewed by Cell Stem Cell; News reports by Nature, Science and MIT Technology Review).

6. Hao Li*, Dengyu Lu, Haiou Liao, Jiaqi Zhang, Jing Tang, Fang He, Ling Li, Yuzhen Zhang, Xiangqing Leng, Chengyu Li, Mu-ming Poo,* and Zhen Liu*. A mesoscale optogenetics system for precise and robust stimulation of the primate cortex. Neuron. 2026, 114: 1-15.

7. Zhen Liu, Yijun Cai, Yan Wang, Yanhong Nie, Chenchen Zhang, Yuting Xu, Xiaotong Zhang, Yong Lu, Zhanyang Wang, Muming Poo, Qiang Sun. Cloning of macaque monkeys by somatic cell nuclear transfer. Cell, 2018,172:881-887. (Cover story; Previewed by Cell; News reports by Nature and Science).

8. Zhen Liu#, Xiao Li#, Jun-Tao Zhang, Yi-Jun Cai, Tian-Lin Cheng, Yan Wang, Chen-Chen Zhang, Yan-Hong Nie, Wen-Jie Bian, Ling Zhang, Jian-Qiu Xiao, Bin Lu, Yue-Fang Zhang, Xiao-Di Zhang, Xiao Sang, Jia-Jia Wu, Xiu Xu, Zhi-Qi Xiong, FengZhang, Xiang Yu, Neng Gong, Wen-Hao Zhou, Qiang Sun*, Zilong Qiu*. Autism-like behaviours and germline transmission in transgenic monkeys overexpressing MeCP2. Nature, 2016, 530:98-102. (News reports by Nature).

9. Zhen Liu†,*, Yijun Cai†, Zhaodi Liao†, Yuting Xu, Yan Wang, Zhanyang Wang, Xiaoyu Jiang, Yuzhuo Li, Yong Lu, Yanhong Nie, Xiaotong Zhang, Chunyang Li,Xinyan Bian, Mu-ming Poo, Hung-Chun Chang*, Qiang Sun*. Cloning of a Gene-edited Macaque Monkey by Somatic Cell Nuclear Transfer. 2019, National Science Review, 6(1):101-108.

10. Zhen Liu, Yan-Hong Nie, Chen-Chen Zhang, Yi-Jun Cai, Yan Wang, Hui-Ping Lu, Yu-Zhuo Li, Cheng Cheng, Zi-Long Qiu, Qiang Sun*. Generation of macaques with sperm derived from juvenile monkey testicular xenografts. 2015, Cell Research, 26: 139-142

11. Hongyu Chen, Qingtong Tan, Li Li, Lanxin Li, Jiqiang Fu, Wencheng Zhu, Jie Li, Yining Wang, Shiyan Li, Huimin Li, Yidi Sun, Qiang Sun, Zongyang Lu, Zhen Liu. Refined DNA repair manipulation enables a universal knock-in strategy in mouse embryos. Nature Communications, 2025, 16:6502

12. Wencheng Zhu#, Yufeng Ding#, Juan Meng#, Lei Gu#, Wenjun Liu#, Li Li, Hongyu Chen, Yining Wang, Ziyi Li, Chen Li*, Yidi Sun* and Zhen Liu*. Reading and writing of mRNA m6A modification orchestrate maternal-to-zygotic transition in mice. Genome Biology, 2023, 24:67.

13. Hongyu Chen1†, Xingchen Liu†, Lanxin Li†, Qingtong Tan, Shiyan Li, Li Li, Chunyang Li, Jiqiang Fu, Yong Lu, Yan Wang, Yidi Sun, Zhen‐Ge Luo, Zongyang Lu*, Qiang Sun* and Zhen Liu*. CATI: an efficient gene integration method for rodent and primate embryos by MMEJ suppression. Genome Biology ,2023, 24:146.

14. Zhaodi Liao#, Jixiang Zhang#, Shiyu Sun#, Yuzhuo Li, Yuting Xu, Chunyang Li, Jing Cao, Yanhong Nie, Zhuoyue Niu, Jingwen Liu, Falong Lu*, Zhen Liu*, Qiang Sun*. Reprogramming mechanism dissection and trophoblast replacement application in monkey somatic cell nuclear transfer. 2024, Nature Communications (2024)15:5. (News reported by Nature and Science, Highlighted by Nature Communications)

15. Zongyang Lu#, Siting He#, Jian Jiang#, Ling Zhuang#, Yan Wang, Guang Yang, Xiaoyu Jiang, Yanhong Nie, Jiqiang Fu, Xiaotong Zhang, Yong Lu, Xinyan Bian, Hung-Chun Chang, Zhiqi Xiong, Xingxu Huang*, Zhen Liu*, and Qiang Sun*. Base-edited cynomolgus monkeys mimic core symptoms of STXBP1 encephalopathy. 2022, Molecular Therapy. Vol. 30 No 6. (Cover story and highlight by Molecular Therapy)

16. Zhen Liu#*, Kui Li#, Yijun Cai#, Qiming Liu, Tikui Zhang, Yong Lu, Yanhong Nie, Yan Wang, Zhiguang Yan, Yuzhuo Li, Zhanyang Wang, Zhi-Qi Xiong*, Qiang Sun*. Accelerated passage of gene-modified monkeys by hormone-induced precocious puberty. 2021, National Science Review. Jul; 8(7): nwab083.

17. Peiyuan Qiu#, Jian Jiang#, Zhen Liu#, Yijun Cai, Tao Huang, Yan Wang, Qiming Liu, Yanhong Nie, Fang Liu, Jiumu Cheng, Qing Li, Yun-Chi Tang, Mu-ming Poo, Qiang Sun*, Hung-Chun Chang*. BMAL1 knockout macaque monkeys display reduced sleep and psychiatric disorders. 2019, National Science Review. 6(1):87-100

18. Zhanyang Wang, Yuzhuo Li, Xianfa Yang, Yan Wang, Yanhong Nie, Yuting Xu, Xiaotong Zhang, Yong Lu, Tikui Zhang, Qiming Liu, Naihe Jing, Zhen Liu* and Qiang Sun*. Mitochondrial replacement in macaque monkey offspring by first polar body transfer. 2021, Cell Research, 31, 233–236


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  • 国内外动物采购
  • 国内外动物采购
  • 实验动物饲养管理;动物品系统计
  • 转基因动物制备;胚胎冷冻保存;新进品系净化移植
  • 设施环境检测、动物健康监控
  • 动物行为学实验(大、小鼠)
  • 人员培训
  • 国内外动物采购
  • 韩 玲:鼠房主管,高级工程师

    学 历:硕士, 2006, 安徽农业大学, 预防兽医专业 

    专 长:预防兽医、实验动物

    电 话:(021) 54921748; 54921798

    电 邮:hanling@@ion.ac.cn

  • 韩 玲:鼠房主管,高级工程师

    学 历:硕士, 2006, 安徽农业大学, 预防兽医专业 

    专 长:预防兽医、实验动物

    电 话:(021) 54921748; 54921798

    电 邮:hanling@@ion.ac.cn

  • 韩 玲:鼠房主管,高级工程师

    学 历:硕士, 2006, 安徽农业大学, 预防兽医专业 

    专 长:预防兽医、实验动物

    电 话:(021) 54921748; 54921798

    电 邮:hanling@@ion.ac.cn

  • 韩 玲:鼠房主管,高级工程师

    学 历:硕士, 2006, 安徽农业大学, 预防兽医专业 

    专 长:预防兽医、实验动物

    电 话:(021) 54921748; 54921798

    电 邮:hanling@@ion.ac.cn

  • 韩 玲:鼠房主管,高级工程师

    学 历:硕士, 2006, 安徽农业大学, 预防兽医专业 

    专 长:预防兽医、实验动物

    电 话:(021) 54921748; 54921798

    电 邮:hanling@@ion.ac.cn

  • 韩 玲:鼠房主管,高级工程师

    学 历:硕士, 2006, 安徽农业大学, 预防兽医专业 

    专 长:预防兽医、实验动物

    电 话:(021) 54921748; 54921798

    电 邮:hanling@@ion.ac.cn

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